CA125 elevations are associated with which cancers?

CA125 elevations are associated with which cancers?

• A. Ovarian cancer and GI cancer
• B. Pancreatic cancer
• C. Liver cancer
• D. Breast cancer

Answer: (A)

CA-125 is a marker most closely tied to ovarian epithelial cancer, since it is produced by ovarian and peritoneal surfaces and often rises with peritoneal involvement or ascites. It can also increase in other conditions that irritate the peritoneum, including GI cancers that have metastasized to the peritoneum. Because of this, elevations are classically seen with ovarian cancer and GI cancers, making that combination the best fit. CA-125 is not a primary marker for pancreatic, liver, or breast cancers, where other markers (like CA 19-9 for pancreatic or others for breast) are typically more informative.

CA-125 is a marker most closely tied to ovarian epithelial cancer, since it is produced by ovarian and peritoneal surfaces and often rises with peritoneal involvement or ascites. It can also increase in other conditions that irritate the peritoneum, including GI cancers that have metastasized to the peritoneum. Because of this, elevations are classically seen with ovarian cancer and GI cancers, making that combination the best fit. CA-125 is not a primary marker for pancreatic, liver, or breast cancers, where other markers (like CA 19-9 for pancreatic or others for breast) are typically more informative.