Increase GGTP + ALP indicates what condition?

Increase GGTP + ALP indicates what condition?

• A. Hepatocellular disease
• B. Biliary obstruction
• C. Normal
• D. Alcoholism

Answer: (B)

When two enzymes tied to bile flow are elevated together, it points to a problem with the biliary system. Alkaline phosphatase comes from the bile ducts, so it rises with cholestasis or biliary obstruction. Gamma-glutamyl transferase is also released in hepatobiliary injury, helping confirm that the source is the liver/biliary tract rather than bone. In hepatocellular disease, you’d expect transaminases (ALT and AST) to predominate and ALP may be only mildly elevated. Alcohol-related changes can raise GGT, but ALP isn’t necessarily elevated in the pattern seen with obstruction. So the combination of increased GGT and ALP best indicates biliary obstruction.

When two enzymes tied to bile flow are elevated together, it points to a problem with the biliary system. Alkaline phosphatase comes from the bile ducts, so it rises with cholestasis or biliary obstruction. Gamma-glutamyl transferase is also released in hepatobiliary injury, helping confirm that the source is the liver/biliary tract rather than bone.

In hepatocellular disease, you’d expect transaminases (ALT and AST) to predominate and ALP may be only mildly elevated. Alcohol-related changes can raise GGT, but ALP isn’t necessarily elevated in the pattern seen with obstruction.

So the combination of increased GGT and ALP best indicates biliary obstruction.