LFT used to evaluate the level of jaundice and monitor hepatitis and cirrhosis.

LFT used to evaluate the level of jaundice and monitor hepatitis and cirrhosis.

• A. GGT
• B. AST
• C. ALP
• D. ALT

Answer: (D)

ALT, alanine aminotransferase, is the most liver-specific enzyme among the standard liver function tests. When liver cells are damaged by hepatitis or chronic liver disease, ALT leaks into the bloodstream, so its level rises in hepatocellular injury. This makes ALT a sensitive marker for monitoring activity in hepatitis and the progression of cirrhosis. GGT and ALP tend to rise with bile duct problems and cholestasis, not primarily with hepatocellular injury, so they’re less directly tied to the level of jaundice or to activity in hepatitis. AST is also in the liver but is less specific, since it’s present in other tissues like muscle and heart. Therefore, ALT best fits the scenario of evaluating jaundice and monitoring hepatitis and cirrhosis.

ALT, alanine aminotransferase, is the most liver-specific enzyme among the standard liver function tests. When liver cells are damaged by hepatitis or chronic liver disease, ALT leaks into the bloodstream, so its level rises in hepatocellular injury. This makes ALT a sensitive marker for monitoring activity in hepatitis and the progression of cirrhosis.

GGT and ALP tend to rise with bile duct problems and cholestasis, not primarily with hepatocellular injury, so they’re less directly tied to the level of jaundice or to activity in hepatitis. AST is also in the liver but is less specific, since it’s present in other tissues like muscle and heart. Therefore, ALT best fits the scenario of evaluating jaundice and monitoring hepatitis and cirrhosis.