There is no increase in which enzyme with an isolated biliary obstruction?

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Multiple Choice

There is no increase in which enzyme with an isolated biliary obstruction?

Explanation:
In biliary obstruction, the pattern is cholestatic. Bile flow blockage causes a rise in enzymes associated with the biliary system, mainly alkaline phosphatase and gamma-glutamyl transferase. The enzymes that reflect hepatocellular injury, like AST, are not typically elevated in isolated obstruction because the hepatocytes aren’t being damaged directly. So, in a pure biliary obstruction, AST tends to remain normal while ALP and GGT rise. Transaminases may be normal or only mildly elevated if there’s secondary hepatocellular stress, but a prominent rise in AST is not expected.

In biliary obstruction, the pattern is cholestatic. Bile flow blockage causes a rise in enzymes associated with the biliary system, mainly alkaline phosphatase and gamma-glutamyl transferase. The enzymes that reflect hepatocellular injury, like AST, are not typically elevated in isolated obstruction because the hepatocytes aren’t being damaged directly. So, in a pure biliary obstruction, AST tends to remain normal while ALP and GGT rise. Transaminases may be normal or only mildly elevated if there’s secondary hepatocellular stress, but a prominent rise in AST is not expected.

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