Which cell type dominates the liver lobule?

Which cell type dominates the liver lobule?

• A. Endothelial cells
• B. Stellate cells
• C. Hepatocytes
• D. Cholangiocytes

Answer: (C)

Hepatocytes. They form the bulk of the liver parenchyma, arranged in plates that radiate from the central vein. These cells handle the liver’s main tasks—metabolism, protein synthesis, detoxification, and bile production. They make up the vast majority of liver mass, so they dominate the lobule’s cellular composition. The other cell types are present but far less numerous: endothelial cells line the sinusoidal spaces between hepatocyte plates; stellate cells reside in the space of Disse and are more about storage and fibrosis potential; cholangiocytes line the bile ducts in the portal tracts, not throughout the lobule.

Hepatocytes. They form the bulk of the liver parenchyma, arranged in plates that radiate from the central vein. These cells handle the liver’s main tasks—metabolism, protein synthesis, detoxification, and bile production. They make up the vast majority of liver mass, so they dominate the lobule’s cellular composition. The other cell types are present but far less numerous: endothelial cells line the sinusoidal spaces between hepatocyte plates; stellate cells reside in the space of Disse and are more about storage and fibrosis potential; cholangiocytes line the bile ducts in the portal tracts, not throughout the lobule.