Which condition is associated with immunosuppressive therapy and Epstein-Barr virus causing B lymphocyte proliferation after transplantation?

Which condition is associated with immunosuppressive therapy and Epstein-Barr virus causing B lymphocyte proliferation after transplantation?

• A. Hepatic adenoma
• B. Post-transplant lymphoproliferative disorders
• C. Hepatic hemangioma
• D. Cholangiocarcinoma

Answer: (B)

Immunosuppressive therapy after transplantation reduces T-cell surveillance, letting Epstein-Barr virus–infected B cells proliferate unchecked. This drives post-transplant lymphoproliferative disorders, a spectrum that can range from benign B-cell hyperplasia to malignant lymphoma and can involve the liver, graft, lymph nodes, or spleen. In the abdomen, PTLD may present as focal hepatic lesions or nodal enlargement, making it a key consideration in post-transplant patients with new abdominal findings. The other diseases listed are not driven by EBV in the setting of immunosuppression after transplant, so they don’t fit this scenario.

Immunosuppressive therapy after transplantation reduces T-cell surveillance, letting Epstein-Barr virus–infected B cells proliferate unchecked. This drives post-transplant lymphoproliferative disorders, a spectrum that can range from benign B-cell hyperplasia to malignant lymphoma and can involve the liver, graft, lymph nodes, or spleen. In the abdomen, PTLD may present as focal hepatic lesions or nodal enlargement, making it a key consideration in post-transplant patients with new abdominal findings. The other diseases listed are not driven by EBV in the setting of immunosuppression after transplant, so they don’t fit this scenario.