Which condition shows cortical scarring of the cortex due to chronic inflammation and urinary reflux?

Which condition shows cortical scarring of the cortex due to chronic inflammation and urinary reflux?

• A. Chronic Pyelonephritis
• B. Acute Glomerulonephritis
• C. Xanthogranulomatous Pyelonephritis
• D. Malakoplakia

Answer: (A)

Chronic pyelonephritis is marked by recurrent infections that chronically inflame renal tissue, and vesicoureteral reflux allows these infections to persist, causing scarring of the renal cortex. This cortical scarring with associated thinning and calyceal distortion is a classic imaging feature of chronic reflux-related pyelonephritis. The other conditions involve different processes: acute glomerulonephritis mainly affects the glomeruli with inflammation, xanthogranulomatous pyelonephritis causes destructive tissue replacement by granulomatous material often with stones, and malakoplakia is a granulomatous infection with Michaelis-Gutmann bodies—none are defined by cortical scarring from chronic inflammation due to reflux.

Chronic pyelonephritis is marked by recurrent infections that chronically inflame renal tissue, and vesicoureteral reflux allows these infections to persist, causing scarring of the renal cortex. This cortical scarring with associated thinning and calyceal distortion is a classic imaging feature of chronic reflux-related pyelonephritis. The other conditions involve different processes: acute glomerulonephritis mainly affects the glomeruli with inflammation, xanthogranulomatous pyelonephritis causes destructive tissue replacement by granulomatous material often with stones, and malakoplakia is a granulomatous infection with Michaelis-Gutmann bodies—none are defined by cortical scarring from chronic inflammation due to reflux.